This signalling occurs via a Gq protein, to activate phospholipase C and subsequently increase intracellular calcium. Increases thirst sensation and stimulates anti-diuretic hormone (ADH) releaseĮffects of Angiotensin II Cardiovascular EffectsĪngiotensin 2 acts on AT1 receptors found in the endothelium of arterioles throughout the circulation to achieve vasoconstriction. ![]() These will be discussed in more detail below. The table below outlines its effect at different points. It binds to one of two G-protein coupled receptors, the AT1 and AT2 receptors. ![]() Binding of Angiotensin IIĪngiotensin II exerts its action by binding to various receptors throughout the body. ![]() This conversion occurs mainly in the lungs where ACE is produced by vascular endothelial cells, although ACE is also generated in smaller quantities within the renal endothelium. By OpenStax College, via Wikimedia Commonsįig 1 – The juxtaglomerular apparatus demonstrated as a diagram, accompanied by an electron micrograph of it in situ Production of Angiotensin IIĪngiotensinogen is a precursor protein produced in the liver and cleaved by renin to form angiotensin I.Īngiotensin I is then converted to angiotensin II by angiotensin converting enzyme (ACE).
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